Glucose is another substance that is normally retained by the kidneys, so its presence in your urine (glycosuria) is abnormal and may be an indication of diabetes mellitus. Symptoms of diabetes include fatigue, dry mouth, dry skin, excessive thirst (polydipsia), excessive urine output (polyuria) and increased appetite(polyphagia), and the inability to heal wounds properly. Weight loss in spite of increased food intake is also another symptom of diabetes.

Ketonuria (or ketonaciduria), which is the presence of ketones in the urine can also be clinically significant and can indicate unmanaged diabetes mellitus, but can also be present any time the body does not have a sufficient supply of carbohydrates and breaks down fatty tissue to provide alternative energy. The presence of ketones in the urine is also very common in starvation.

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