After Watson and Crick published their model of DNA, the pressing debate in the field was whether DNA replication is conservative, semi-conservative or dispersive. View this video to understand what these three proposals were https://dnalc.cshl.edu/view/15880-Models-of-DNA-replication.html

The seminal experiment done by Matthew Meselson and Franklin Stahl at CalTech in 1957-1958 answered that question.

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View the following video to see what their experiment was and its result. The second video is by Meselson himself telling the story of the experiment and the multiple serendipities that led to it. After viewing these videos, write in the discussion at least 5 sentences sharing what you learned from this experiment about DNA replication and about how knowledge in chemistry can help design experiments to answer important biological questions.


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