Benzodiazepines are a class of medications with a highly personalized chemical structure and consistent pharmacological properties. Their pharmacokinetics and metabolism distinguish them to a large extent, so they must be used with caution. These are weak acids with high lipophilicity and variable constant dissociation, which allows for rapid passage through membranes (blood-brain and placental barriers, as well as the path in breast milk) . Except for chlordiazepoxide, dipotassium clorazepate, and midazolam, almost all benzodiazepines are insoluble in water, necessitating the use of organic solutions for parenterally administrable versions. These sedatives are frequently used only for the relief of acute anxiety. If you have a history of alcohol or drug abuse, these medications are not a good choice because they can become habit-forming. In extreme cases. Patients with a history of the benzodiazepine or other substance abuse should not be treated with this class of medication. Benzodiazepines can be combined with SSRIs/SNRIs in the weeks preceding the antidepressant’s onset of efficacy.

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